Sabine Andrea Huber | Project student
Sabine is a medical student from Germany and has already accumulated a wide range of experience. She has done laboratory work at the Department of Medical and Molecular Genetics at King’s College in London and clinical work from neurology and neurosurgery in hospitals. Sabine is excited about expanding her knowledge about neuroscience and dive into a new field for the next six months.
Sabine Andrea Huber | Project student
Britt Veldman | Master student
After her bachelor degree in Psychobiology from Amsterdam, Britt worked as a teaching assistant and tutor for two years. She then decided to come to NTNU for her masters in Neuroscience. Here, she found a little bit of the Netherlands in our group in Trondheim and will do her project together with Jacob Bellmund.
Ignacio Polti | Research assistant
During his master program in Psychology at the University of Buenos Aires (Argentina), Ignacio was a research intern at the Behavioral Biology Lab, where he studied electrophysiological correlates of semantic networks. He continued to do a master program in Cognitive Sciences at the École Normale Supérieure in Paris (France), studying psychophysical and electromagnetic signatures of human time perception. In our group, he will assist research on time estimation and uncertainty.
Annelene Gulden Dahl | PhD candidate
Annelene is enrolled in a PhD programme in Lisbon (Portugal), but will collect the remaining data in our lab in Trondheim for the next couple of years. She will be working on a rodent MRI project trying to bridge the gap between much of the ongoing rodent research and the human MRI research at the Kavli Institute.
Gøril Rolfseng Grøntvedt | PhD candidate
Gøril is a consultant neurologist in the Department of Neurology at St. Olavs Hospital with a special interest for early onset Alzheimers disease (AD). She is also a PhD student in search of biomarkers in preclinical/early phase of AD. In order to do that, she will look at spatial cognition and fMRI-based measures of hippocampal processing in AD patients.
Dörte Kuhrt | PhD candidate
Our last, but not least, additon to the group is Dörte. She is now starting to work towards her PhD focusing on the representation of conceptual spaces. As Dörte knows a little bit of everything, she is our very own oracle. Before she joined the group she did her bachelors and masters degree in Cognitive Science at the University of Tübingen with a focus on neuroscience and human memory.
We had an amazing time at our Lab Retreat and are extremely grateful to have had fantastic guests with us. A special thanks goes to Howard Eichenbaum who visited our group and shared inspiring insights into how temporal and spatial information is combined into memories and how conceptual knowledge might be processed by the brain.
It is essential for everyday life to remember not only the spatial relationships in our environment (‘My GP’s office is 500 metres south of the new fast food restaurant’), but also the temporal relationship between events (‘I got food poisoning after I had lunch at the new fast food restaurant’). In our new study, published in eLife, we show that remembering both kinds of information relies on similar neural mechanisms.
Spatial and temporal relationships are usually not independent of one another: If something is further away, it also takes longer to get there. Previous studies have shown that a brain region called the hippocampus is involved in both memory for spatial layouts as well as for temporal relationships, however, few studies have investigated the two dimensions simultaneously.
To investigate memory for time and space separately in the same experiment, we let participants navigate through a computer game-like virtual city (‘Donderstown’) in which they picked up different objects along a pre-defined route. Over time, participants learned which object was encountered where and when. Crucially, at certain points along the route, participants had to use teleporters, which immediately ‘beamed’ them to a different part of the city. This way, certain objects along the route could be very far apart in space, but be encountered closely after one another in time.
Using fMRI, we then monitored brain activity while participants watched these objects and examined which impact the newly learned spatial and temporal relationships between them had on the hippocampus. Interestingly, we found that – compared to a baseline scan before the virtual navigation – neural patterns in the hippocampus got more similar for objects which were remembered as closer together. This was true for both the spatial closeness, and for the temporal closeness between objects. Moreover, the effect was most pronounced when items were both spatially and temporally close.
Participants collected objects while navigating on different routes within a virtual city (shown from birds-eye view). Some parts of the city were connected via ‘beaming’-teleporters, transporting participants over long distances instantaneously. This way, objects that were far away in space could be encountered very closely in time. Using fMRI, we found that both temporal and spatial relationships change memory related brain patterns.
These findings lead us to believe that neural patterns in the hippocampus reflect a code for representing the relatedness of items or events – possibly along more dimensions than time and space. We propose that the hippocampus contains information of the inter-relatedness between different objects along many different dimensions in the form of an ‘event map’. In the future, it will be exciting to identify other domains which are represented in this way, such as degree of sympathy or emotionality of items. Eventually, this could help us to improve our understanding of neural mechanisms in psychiatric conditions, for example by investigating whether patients suffering from Major Depression might have a ‘skewed’ emotional event map.
For more information, see:
Deuker L, Bellmund JLS, Navarro Schröder T, Doeller CF (2016). An event map of memory space in the hippocampus. eLife
Episodic memories are made up of different pieces of information, for instance where the event took place, who was there and when it happened. How does the brain combine these pieces into one coherent memory? In the latest study from our lab, we show that a specialized structure deep inside the brain, called the hippocampus, plays a central role in this binding process. The results were published in the journal Nature Communications.